Guillermo Alexander's current research focuses on the study of pro- and anti-inflammatory cytokines, amino acids, neuroactive peptides and biogenic amines found in the blood and cerebrospinal fluid of patients with complex regional pain syndrome (CRPS)/reflex sympathetic dystrophy (RSD). These studies could shed light on the mechanisms that bring about exaggerated pain and could aid in the development of more effective treatment modalities.
In another series of studies he is utilizing a transgenic mouse model for ALS to study the effect of genetic background on the severity of the disease.