The proper gene expression program is regulated at the transcription level through the interplay among epigenetic, trans- (e.g. transcription factor, chromatin modifier) and cis-regulatory (e.g. promoter, enhancer) elements, and disruption of transcriptional regulatory network causes human diseases, such as degenerative disorder and cancer. We are a functional genomics lab focusing on the fundamental gene regulation mechanism that control tissue repair and cancer development. Our lab use muscle stem cell, rhabdomyosarcoma (a life-threatening pediatric sarcoma), and glioblastoma as model system, and work at the intersection of functional genomics, cell biology and bioengineering, to employ integrative approaches including (but not limited to) epigenome and 3D-genome analysis, high-throughput genome and epigenome editing, single-cell genomics, animal model, human stem cell and organoid system, for understanding and treating complex disorders related to tissue regeneration, aging, and cancer.
