We have used these tools to measure the effect of genetic variation and its contribution to rare and common disease, to understand the complexity of the genetic architecture of such disorders, to dissect biochemical pathways, and to develop new drug screening paradigms. Although our studies fall under four broadly defined thematic areas outlined below, these are subject to substantial crosstalk, reflective of the overlapping interests of our faculty and of the multidisciplinary nature of the CHDM.
