Our lab is interested in the genetic engineering of negative sense RNA viruses, particularly respiratory viruses such as influenza viruses. These manipulated viruses, together with transgenic animal models, allow us to ask novel questions about the biology of viral infections. We have established systems that allow for the tagging of viral proteins as well as the insertion of entire genes with minimal costs to the virulence of the virus. These platforms allow us to generate novel viral tools for probing specific aspects of viral infections not previously possible.
