Our laboratory focuses on identifying and characterizing the bacterial factors that are secreted across the inclusion to manipulate eukaryotic cellular functions. We use a combination of cell biological techniques, biochemistry, genetics, genomics, proteomics and molecular biology to determining the function of chlamydial virulence factors that reveal novel facets of the cell biology of host-pathogen interactions and how these factors are translocated into the host. We also have developed new methods to perform genetic analysis in these formerly genetically intractable bacteria which we have now extended to other microbes of importance in human health.
