My laboratory studies ion channels, transporters, and signalling pathways that associated with human diseases, for examples, stroke that regulated by WNK-SPAK/OSR1-KCC2/NKCC1, hypertension that regulated by WNK-SPAK/OSR1-NCC, and concern with elucidating and targeting ion transporters, kinases, protein-protein interactions using genetic mouse models, small molecules, CRISPR/Cas9 gene-editing technologies, and electrophysiology to aid discovery and validation of new potential drug targets.
