My research focuses on understanding the epigenetic mechanisms governing the biology of stem cells, development and cancer with an emphasis on the role of DNA modifying enzymes DNMTs and Tets in DNA (de)methylation and hydroxymethylation in pluripotent, multipotent and germ cells. We utilize embryonic stem cells, induced pluripotent stem cells and mice as model systems to study how these enzymes reshape the epigenome and regulate development and cancer. The lab specializes in state-of-the-art technologies of genome engineering in mouse and human embryonic stem cells and iPSCs and generating complex strains of conditional, inducible, transgenic and knockout mice to dissect epigenetic pathways and mechanisms in vitro and in vivo
